About 2 years ago, NitroMed garnered a lot of publicity and a lot of debate when it won approval for BiDil, a heart failure drug for black people. On one side of the debate were people who thought that medicines that were closely targeted at specific populations could provide advances in healthcare. On the other side were those who argued that race is a poorly defined biological characteristic and that most race-based differences in population health are due to the environment.
Nitromed just reported its 1Q earnings and … they suck, to put it bluntly. The drug has had just $3.2 million in sales, according to analysts Friedman Billings Ramsey.
FBR’s analysis:
"The company continues to gain formulary acceptance for BiDil, but prescriptions, which peaked in October last year, have not demonstrated any meaningful improvement …"
"Management intends to add an additional 30 personnel to support its marketing effort during the next two quarters."
"At the end of 1Q07, the company had $32.5 million of cash, representing a decline of $9.5 million, compared with the end of 2006. At the current burn rate, NTMD has a little more than three quarters of cash remaining."
My opinion: Whether the science is there or not, without funding or demand it's not going forward. One possible factor is that the FDA approval was for "self-identified black patients." The problem with that is that a lot of people turn out to be not as black -- or white, or whatever -- as they think they are when their DNA is examined. Nicholas Kristoff examined the issue in this NYT column, in which he revealed that despite thinking he was white, genetic testing reveals he has Ethiopian genes.

Jim,
I think the "not-as-black-as-you-think" gene hypothesis is bogus and even if true certainly not repsonsible for lackluster BiDil sales.
My blog post this morning places the blame squarely on marketing. Your post is referenced there. See http://pharmamkting.blogspot.com/2007/05/bidil-sales-disappoint-blame-genes-or.html
John
Posted by: John Mack | May 04, 2007 at 09:43 AM
IMO, the key BiDil problem is not self-identification of being black, as reported here, nor is it ineffective marketing, as reported by John Mack (although this is an important factor in all disappointing launches). The key problem is one of strategy. NitroMed conducted a great trial that proved 2 generic drugs, in combination, worked very effectively in black HF patients. They assumed insurers/patients would pay a premium for a re-formulated version of these 2 drugs that was much more convenient to take (less pills and less pill taking events per day). This proved to be dead wrong, and all NitroMed did was increase the sales of these generics (and possibly provide a nice public service).
Posted by: Chris | May 04, 2007 at 03:46 PM
Chris hits the nail squarely on the head. BiDil is simply two generic drugs. Why would insurance companies and physicians write for/pay for something more expensive?
Posted by: Paul | May 05, 2007 at 01:45 AM
This may be a bit random, but:
I am a medical student doing a project for assesment on "What Might Prevent Race Based Medicine from having a Future in Medical Treatment?"
And I was wondering if anyone knew of any sites/online accessible artiles that may be of use.
Would appreciate any responsed
Thanks
Emily
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According to Jim Edwards, editor at Brandweek, sales of BiDil, is a heart failure drug for African Americans.The real problem with BiDil sales may have more to do with inadequate or ineffective marketing than with less-black-than-you-think genes.
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